Fly for sure. I'm thinkging big clousers, minnows, maybe dark super buggers. I guess my question is how to fish them. Chunking at the banks?
BD- Thanks a ton for the help! 
For smallies and spotted bass, you'll mostly be chucking at the banks around current breaks or rock piles. Try superbugger or some other chunky, dark fly that imitates a crawfish.
For stripers, skipjack, white bass, etc, focus on schools of bait if you can find them. The fish may be hanging a little way off the bank in the current, or they may be out in the open water, but most likely they'll be following the bait. Throw something that looks like a shad. Like Mike said, if there's no surface activity, count it down to get deeper, but not deep enough to get into the rocks.
You may want to look into bringing some gar flies - I'm hearing that there are some big ones on the Cumberland right now.
bd
